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Title: Bis(bibenzyls) from liverworts inhibit lipopolysaccharide-induced inducible NOS in RAW 264.7 cells: A study of structure-activity relationships and molecular mechanism Authors: Harinantenaina L. Quang D.N. Takeshi N. Hashimoto T. Kohchi C. Soma G.-I. Asakawa Y. Keywords: Issue Date: 2005 Publisher: Journal of Natural Products Citation: Volume 68, Issue 12, Page 1779-1781 Abstract: The inhibition of lipopolysaccharide-induced NOS by 19 bis(bibenzyls) isolated from liverworts in RAW 264.7 macrophages was evaluated. The presence of phenolic hydroxyls and saturation at 7,8 and/or 7′/8′ are required for inhibition of NO production. Among the compounds tested, marchantin A (1) was the most potent, and its inhibitory activity was consistent with the inhibition of LPS-induced iNOS mRNA. © 2005 American Chemical Society and American Society of Pharmacognosy. URI: http://tainguyenso.vnu.edu.vn/jspui/handle/123456789/11626 ISSN: 1633864 Appears in Collections: Articles of Universities of Vietnam from Scopus
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