Antimicrobial azaphilones from the fungus Hypoxylon multiforme

Abstract

Four new azaphilones named multiformins A - D together with a known compound 4:5:4′:5′-tetrahydroxy-1:1′-binaphthyl were isolated from the methanolic stromatal extract of the xylaria-ceous ascomycete Hypoxylon multiforme. Their absolute structures were characterised by 2D-NMR, UV, IR, mass and CD spectroscopy. Multiformins A - D showed strong and apparently non-selective antimicrobial activity. © Georg Thieme Verlag KG Stuttgart.