Fifteen mixed cis-diamine complexes cis-[Pt(Mor)(Am)Cl2], Mor: morpholine; Am: aniline, o-toluidine, p-toluidine, p-anisidine, p-phenetidine, α-naphthylamine, pyridine, quinoline, 8-oxiquinolinato, benzylamine, 2-phenylethylamine, methylamine, dimethylamine, ethylamine and diethylamine have been prepared. The structures of the complexes have been examined by elemental analysis, molar conductivity, UV, IR, Raman and 1H NMR spectra. Spin-spin splitting patterns of non-equivalent protons Hαa, Hαe, Hβa, Hβe of morpholine have been designated. The morpholine ring has a chair conformation with nitrogen bound equatorially to Pt. The examined complexes have a cis-configuration in which the planes of the aromatic amine and morpholine rings are perpendicular to the coordination plane of Pt(II). The complexes were tested for cytotoxicity: cis-[Pt(Mor)(PhCH 2NH2)Cl2], cis-[Pt(Mor)(PhCH2CH 2NH2)Cl2] and cis-[Pt(Mor)(OC9H 6N)Cl] exhibit anticancer activities in vitro on human cancer cell Hep-G and RD with IC50 < 5 μg cm-3.
