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Tai Nguyen So - Vietnam National University, Ha Noi - VNU >
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| Title: | Antiproliferative activity of cardenolides isolated from Streptocaulon juventas |
| Authors: | Ueda J.-Y.
Tezuka Y.
Banskota A.H.
Tran Q.L.
Tran Q.K.
Saiki I.
Kadota S. |
| Keywords: | Antiproliferative activity
Apoptosis
Cardenolides
Human HT-1080 fibrosarcoma
Human lung A549 adenocarcinoma
Streptocaulon juventas |
| Issue Date: | 2003 |
| Publisher: | Biological and Pharmaceutical Bulletin |
| Citation: | Volume 26, Issue 10, Page 1431-1435 |
| Abstract: | Sixteen cardenolides, two hemiterpenoids, two phenylpropanoids and a phenylethanoid isolated from the roots of Streptocaulon juventas (LOUR.) MERR. were examined for their antiproliferative activity toward three human-derived (HT-1080 fibrosarcoma, lung A549 adenocarcinoma, cervix HeLa adenocarcinoma) and three murine-derived (colon 26-L5 carcinoma, Lewis lung carcinoma, B16-BL6 melanoma) cell lines. The cardenolides selectively and strongly inhibited proliferation of the HT-1080 (IC50 values, 0.054-1.6 μM) and A549 (IC50, 0.016-0.65 μM) cell lines. The characteristic morphological changes and ladder-like DNA fragmentation in those cells treated with the cardenolides indicated the antiproliferative activity was due to the induction of apoptosis. © 2003 Pharmaceutical Society of Japan. |
| URI: | http://tainguyenso.vnu.edu.vn/jspui/handle/123456789/12676 |
| ISSN: | 9186158 |
| Appears in Collections: | Articles of Universities of Vietnam from Scopus
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