Technical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, NSTI-Nanotech, Nanotechnology 2008
Citation:
Volume 3, Issue , Page 347-350
Abstract:
The objective of the paper is to develop a "lab-on-a-chip" device for early disease (pancreatic cancer) diagnosis by using ferromagnetic resonance (FMR). Magnetic microbeads, which are functionalized for target molecules (antigens), are immobilized by antigen-antibody reactions on the surface of a microwave circuit. These magnetic labels are detected inductively using FMR, which detects a single bead with a sensitivity of 1-10 μV/V. This method has distinctive advantages compared to other conventional immunoassay techniques; it requires a small sample volume, is non-invasive, cost effective, and easy to implement. It also does not alter the native properties of the antigen and antibody complex.
