15 epileoheteronone b 15 epileoheteronone d 15 epileoheteronone e 15 epileopersin b diterpenoid galeopsin hispanone Leonurus heterophyllus extract drug accumulation drug determination Leonurus heterophyllus Magnetic Resonance Spectroscopy
Issue Date:
2005
Publisher:
Chemical and Pharmaceutical Bulletin
Citation:
Volume 53, Issue 11, Page 1475-1479
Abstract:
Twelve natural bis-spirolabdane-type diterpenoids, including eight new, named leoheteronones AE
(3, 6, 8, 9, 11), 15-epileoheteronones B (7), D (10), and E (12), and four known leopersin B (1), 15-
epileopersin B (2), leopersin C (4), and 15-epileopersin C (5), together with hispanone (13) and galeopsin
(14) were isolated from the aerial parts of the medicinal plant Leonurus heterophyllus Sw. (Lamiaceae)
grown in Vietnam. Their structures were determined by spectroscopic analyses. The current study
emphasized the accumulation of C-15 oxygenated bis-spirolabdane-type diterpenoids of both 13R and 13S
configurations in L. heterophyllus. ?? 2005 Pharmaceutical Society of Japan.
