Anti-inflammatory activity Erythrophleum fordii Oliv Cassaine-type diterpenoids 1,1 diphenyl 2 picrylhydrazyl diterpenoid erythrofordin a erythrofordin b norerythrofordin a taraxerol Erythrophleum fordii legume microglia nonhuman Animals Cells, Cultured Diterpenes
Issue Date:
2008
Publisher:
Bioorganic and Medicinal Chemistry
Citation:
Volume: 16, Issue: 22, Page : 9867-9870
Abstract:
A phytochemical investigation of the leaves of Erythrophleum fordii Oliv. has led to the isolation
of three new cassaine-type diterpenoids, erythrofordin A (1), erythrofordin B (2) and erythrofordin C (3), as
well as a norcassaine diterpenoid with a novel skeleton, norerythrofordin A (4), and 27 known compounds
(5-31). The structures of 1-4 were elucidated on the basis of spectroscopic analysis. Selected compounds
from this plant were examined for anti-inflammatory activity. Taraxerol (16) displayed potent NO-reducing
activity in microglial cells, and gallic acid (27) exhibited excellent DPPH radical-scavenging effects. Crown
Copyright ?? 2008.
