Four new furanoditerpenoids, fibrauretin A (1), fibrauretinoside A (2), epi-fibrauretinoside A (3),
and epi-2-palmatoside G (4), and a new ecdysteroid glucoside, fibraurecdyside A (5), together with seven
known compounds including two furanoditerpenoids (6 and 7), an ecdysteroid (8), and four quaternary
protoberberine alkaloids (9-12) were isolated from the stems of Fibraurea tinctoria. The structures of 1-5
were established on the basis of spectroscopic evidence. Among these compounds, palmatine (9) and
jatrorrhizine (10) showed inhibitory effects against cytochrome P450 3A4 (CYP3A4) with IC50 values of
0.9 and 2.1 ?M, respectively. ?? 2007 American Chemical Society and American Society of
Pharmacognosy.
