The methanolic extract of Piper lolot, having shown potent inhibitory activity on platelet
aggregation induced by arachidonic acid (AA) and platelet activating factor (PAF), was subjected to
activity-guided isolation to yield twelve new amide alkaloids, piperlotine A-L (1-12), along with twentynine
known compounds. Their structures were elucidated on the basis of spectroscopic analysis. The isolated
compounds were tested for their inhibitory activity on the rabbit platelet aggregation. The compounds
piperlotine A (1), piperlotine C (3), piperlotine D (4), piperlotine E (5), 3-phenyl-1-(2,4,6-trihydroxyphenyl)
propan-1-one (21), 3-(4-methoxyphenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-one (22), 1-transcinnamoylpyrrolidine
(24), sarmentine (26), pellitorine (27), methyl 3-phenylpropionate (32), and (10S)-10-
hydroxypheophorbide a methyl ester (40) showed potent antiplatelet aggregation activity. ?? 2007 American
Chemical Society.
