NF-?B NO production Zerumbone Zerumbone-2,3-epoxide
Issue Date:
2009
Publisher:
Scientia Pharmaceutica
Citation:
Volume 77, Issue 3, Page 589-595
Abstract:
In the present study the significant role of the ?,?-unsaturated carbonyl structure in the antiinflammatory
activity of the natural humulane sesquiterpenoids zerumbone and zerumbone 2,3-epoxide was
evidenced from a comparative study of the ability of zerumbone and zerumbone 2,3-epoxide to inhibit NF-
?B activation and NO production in LPS (lipopolysaccharide)- stimulated RAW 264.7 cells. The IC50 of
these compounds were 1.97 ?M ? 0.18 and 30.11 ?M ? 4.10 in the NF-?B activation assay and 3.58 ?M ?
0.46 and 34.7 ?M ? 3.72 in the nitric oxide production assay, respectively. ?? Giang et al.; licensee
??sterreichische Apotheker-Verlagsgesellschaft m. b. H.
