From the aerial parts of Scoparia dulcis L. (Scrophulariaceae) grown in Vietnam, four
scopadulane-type diterpenoids (4-7), of which 7 is new and was given the trivial name scopadulcic acid C,
together with nine known compounds were isolated. Their structures were elucidated by spectroscopic
analyses. The absolute con-figurations of 4-7 were ascertained by applying the modified Mosher's method to
iso-dulcinol (6). The isolation of the lignans nirtetralin and niranthin for the first time from S. dulcis is also
of chemotaxonomic interest. The cytotoxic activity in KB cells, inhibitory effect on LPS/IFN??-induced NO
production, inhibition of multidrug resistance (MDR), and antibacterial and antifungal activities of the
scopadulane-type diterpenoids 4-7 were examined in this study. ?? 2006 Pharmaceutical Society of Japan.
