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Abstract:
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Some 2-amino-4,6-diarylpyrimidines 2 have been prepared from substituted
benzylideneacetophenones and guanidine hydrochloride in the presence of alkali by conventional heating in
alcoholic medium and microwave heating in solvent-free conditions. N-(2,3,4,6-Tetra-O-acetyl-?-dglucopyranosyl)-
N?-(4?,6?-diarylpyrimidin-2?-yl)thioureas 4 have been synthesized by reaction of per-Oacetylated
glucopyranosyl isothiocyanate 1 and substituted 2-amino-4,6-diarylpyrimidines 2. Two different
methods have been used, namely, refluxing in anhydrous dioxane and solvent-free microwave-assisted
coupling. The second procedure afforded higher yields in much shorter reaction times. The compounds 2
and 4 were tested for their antibacterial and antifungal activities in vitro against Staphylococcus epidermidis,
Enterobacter aerogenes and Candida albicans by disc diffusion method. ?? 2009 Elsevier Ltd. All rights
reserved. |