| dc.contributor.author |
N.D., Thanh |
|
| dc.contributor.author |
N.T.T., Mai |
|
| dc.date.accessioned |
2011-05-09T09:42:07Z |
|
| dc.date.available |
2011-05-09T09:42:07Z |
|
| dc.date.issued |
2009 |
|
| dc.identifier.citation |
Volume 344, Issue 17, Page 2399-2405 |
vi |
| dc.identifier.issn |
86215 |
|
| dc.identifier.uri |
http://tainguyenso.vnu.edu.vn/jspui/handle/123456789/7344 |
|
| dc.description.abstract |
Some 2-amino-4,6-diarylpyrimidines 2 have been prepared from substituted
benzylideneacetophenones and guanidine hydrochloride in the presence of alkali by conventional heating in
alcoholic medium and microwave heating in solvent-free conditions. N-(2,3,4,6-Tetra-O-acetyl-?-dglucopyranosyl)-
N?-(4?,6?-diarylpyrimidin-2?-yl)thioureas 4 have been synthesized by reaction of per-Oacetylated
glucopyranosyl isothiocyanate 1 and substituted 2-amino-4,6-diarylpyrimidines 2. Two different
methods have been used, namely, refluxing in anhydrous dioxane and solvent-free microwave-assisted
coupling. The second procedure afforded higher yields in much shorter reaction times. The compounds 2
and 4 were tested for their antibacterial and antifungal activities in vitro against Staphylococcus epidermidis,
Enterobacter aerogenes and Candida albicans by disc diffusion method. ?? 2009 Elsevier Ltd. All rights
reserved. |
vi |
| dc.language.iso |
en |
vi |
| dc.publisher |
Carbohydrate Research |
vi |
| dc.subject |
Glucopyranosyl isothiocyanate |
vi |
| dc.subject |
Glucopyranosyl thiourea |
vi |
| dc.subject |
Microwave-assisted method |
vi |
| dc.subject |
Pyrimidine |
vi |
| dc.title |
Synthesis of N-tetra-O-acetyl-?-d-glucopyranosyl-N?- (4?,6?-diarylpyrimidin-2?-yl)thioureas |
vi |
| dc.type |
Article |
vi |