11alpha acetoxy 7beta,14alpha dihydroxykaur 16 en 15 one 11alpha acetoxykaur 16 en 18 oic acid 11alpha,18 diacetoxy 7beta hydroxykaur 16 en 15 one 15alpha,18 dihydroxykaur 16 ene 18 acetoxy 11alpha hydroxykaur 16 en 15 one 18 hydroxykaur 16 ene 1alpha,14alpha diacetoxy 7beta hydroxy 17 methoxykauran 15 one 7beta acetoxy 11alpha hydroxykaur 16en 15 one Croton tonkinensis extract; diterpenoid kaur 16 en 15 one 18 oic acid plant extract Croton tonkinensis
Issue Date:
2005
Publisher:
Chemical and Pharmaceutical Bulletin
Citation:
Volume 53, Issue 3, Page 296-300
Abstract:
Six new ent-kaurane-type diterpenoids were isolated from the leaves of the endemic Vietnamese
medicinal plant Croton tonkinensis GAGNEP. (Euphorbiaceae) together with three known ent-11?-acetoxy-
7?,14?-dihydroxykaur- 16-en-15-one (1), ent-kaur-16-en-15-one 18-oic acid (5) and ent-18-hydroxykaur-
16-ene (7). Their structures were determined by spectroscopic analyses to be ent-7?-acetoxy-11?-
hydroxykaur-16-en-15-one (2), ent-18-acetoxy- 11?-hydroxykaur-16-en-15-one (3), ent-11?-acetoxykaur-
16-en-18-oic acid (4), ent-15?,18-dihydroxykaur-16-ene (6), ent-11?,18-diacetoxy- 7?-hydroxykaur-16-en-
15-one (8), and ent-(16S)-1?,14?- diacetoxy-7?-hydroxy-17-methoxykauran-15-one (14). ent-Kaurane-type
diterpenoids from Croton tonkinensis 2-4, 6, and 9-13, were tested for toxicity in the brine shrimp lethality
assay. Compounds 9, 10, and 12 demonstrated significant activity, compounds 2, 3, 6, and 11 showed weak
activity, and compounds 4 and 13 were inactive. ?? 2005 Pharmaceutical Society of Japan.
